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Since the creation of the unit in January 2001, we have developed several research programs focusing on epidemiology, physiopathology and immunology of retroviruses \u2013 Human T Lymphotropic viruses-HTLV-1\/2\/3\/4 and their simian counterpart (STLV-1\/3\/4), as well as simian foamy viruses (SFV) and HIV-, as well as herpesviruses (HHV-8), and more recently some emerging viruses, such as Chikungunya.<\/p>\n<\/div>\n<\/div>\n<\/div>\n
1) The first thematic concerns the epidemiology and molecular characterization of retroviruses of zoonotic origin in Central Africa, in order to get better knowledge on the origin and modes of interspecies transmission from monkeys and apes to humans of STLV-1\/HTLV-1, STLV-3\/HTLV-3 and SFV. \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0<\/p>\n
2) The second thematic concerns the molecular epidemiology of 3 oncogenic human viruses: HTLV-1, HHV-8 and Merkel cell Polyomavirus. This led to a better definition of the worldwide distribution of the different viral molecular genotypes, as well as their modes of dissemination mainly by population migrations.<\/p>\n
Furthermore, the unit is recognized as an expert laboratory on the clinical, serological and viro-molecular aspects of HTLV-1\/2 and HHV-8 infections and their associated neurological diseases and tumors with several connections with French and foreign hospital\u2019s departments and animal care facilities.<\/p>\n
Lastly, we have developed strong, long-lasting collaborations with several laboratories of the \u00ab\u00a0R\u00e9seau International des Instituts Pasteur et Instituts associ\u00e9s\u00a0\u00bb (Cameroon, French Guiana, Central African Republic, New Caledonia,\u2026), the CIRMF in Gabon and a Peruvian University in Lima.<\/p>\n
<\/p>\n
1) The mechanisms of mother to child transmission of HTLV-1. These are based on both in vitro and in vivo systems including, in the near future, animal models. In addition to viral transcytosis mechanisms through enterocytes, we are also studying the role of other cell types (dendritic cells, M cells) in the HTLV-1 transport across the intestinal barrier.<\/p>\n
2) The HTLV-1-induced myositis. The main characteristics of HTLV-1 myositis have been assessed both by a virological, anatomopathological and immunological study ex vivo, and by in vitro assessment of human muscle cells susceptibility to HTLV-1. We have also studied the human muscle cells susceptibility to other viruses, such as Influenza, Chikungunia or Sindbis, comparing myoblasts vs myotubes infection by different field isolates.<\/p>\n
3) The HTLV-1 associated neuromyelopathy (TSP\/HAM). We developed studies to understand the mechanisms involved in the lymphocyte interaction with the blood-brain-barrier and also to characterize the induced inflammatory process.<\/p>\n
<\/p>\n
1) The first is the cross-species transmission of foamy virus from apes to human with studies of the adaptive immune response focusing on the presence of neutralizing antibodies. A vast program is currently developed to better understand the natural history of such zoonotic infection in humans, which represents a natural model of viral restriction in vivo.<\/p>\n
2) The second is the HIV pediatric infection in which virus specific responses are generated by an immature immune system in the presence of an immunosuppressive virus. These long-term studies are ongoing in collaboration with the ANRS French perinatal cohort.<\/p>\n
The EPVO unit is also much involved in teaching at the Institut Pasteur with members of the unit being co-director of three courses (Systematic Virology, Fundamental virology and Circulation of Infectious agents).<\/p>\n<\/div>\n<\/div>\n<\/div>\n
Responsable : Antoine GESSAIN<\/p>\n
C\u00e9line Curis : PhD Student
Aurore Vidy-Roche : Permanent Researcher
Thomas Montange
Isma Ziani : Administrative Staff
Patricia Jeannin : Technician
Vincent Legros : PhD Student
Olivier Cassar : Permanent Researcher
Pierre-Emmanuel Ceccaldi : Group Leader
Philippe Afonso : Permanent Researcher
Florence Buseyne : Group Leader
Patricia Tortevoye : Research Engineer
Mathieu Hubert : PhD Student
Damien Batalie : Undergraduate Student
Mathilde Couteaudier : Post-doc
Oc\u00e9ane Dehan : Undergraduate Student<\/p>\n<\/div>\n<\/div>\n<\/div>\n
75015<\/span>\u00a0PARIS<\/span><\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" EPVO \u00a0 UFR de rattachement\u00a0> Sciences du Vivant \u00a0 \u00a0 Label unit\u00e9 > UMR 3569 \u00a0 Partenaires\u00a0> PASTEUR\/CNRS \u00a0 Pr\u00e9sentation Since the creation of the unit in January 2001, we have developed several research programs focusing on epidemiology, physiopathology and immunology of retroviruses \u2013 Human T Lymphotropic viruses-HTLV-1\/2\/3\/4 and their simian counterpart (STLV-1\/3\/4), as… Lire la suite Epid\u00e9miologie et Physiopathologie des Virus Oncog\u00e8nes<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1625","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1625"}],"version-history":[{"count":2,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1625\/revisions"}],"predecessor-version":[{"id":1627,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1625\/revisions\/1627"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}