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Les activit\u00e9s de l’unit\u00e9 sont centr\u00e9es sur la g\u00e9n\u00e9tique mol\u00e9culaire des virus \u00e0 ARN positif ou n\u00e9gatif (virus grippaux, coronavirus associ\u00e9 au SRAS, h\u00e9pacivirus).
Elles portent sur l’\u00e9tude des m\u00e9canismes mol\u00e9culaires de l’expression et de la r\u00e9plication des g\u00e9nomes viraux et de leur emploi comme vecteurs d’expression, l’analyse des interactions fonctionnelles entre le virus et son h\u00f4te, l’\u00e9pid\u00e9miologie mol\u00e9culaire et l’\u00e9tude de la variabilit\u00e9 des g\u00e9nomes viraux ainsi que le d\u00e9veloppement d’approches vaccinales et diagnostiques, notamment pour le SRAS-CoV.<\/p>\n
<\/p>\n
Diagnostic et r\u00e9actifs :<\/strong><\/p>\n – Isolement et amplification des virus grippaux sur \u0153uf embryonn\u00e9 et en culture cellulaire Inhibition des activit\u00e9s biologiques et enzymatiques virales :<\/strong><\/p>\n – Attachement, fusion, multiplication Mod\u00e8le murin d’infection grippale :\u00a0\u00a0<\/strong>\u00a0\u00a0<\/p>\n – Morbidit\u00e9, mortalit\u00e9, clairance virale S\u00e9rologie :<\/strong><\/p>\n – Enqu\u00eates incluant le design de protocoles<\/p>\n – \u00c9valuation de l’activit\u00e9 immunog\u00e9nique de produits vaccinaux lors d’essais cliniques<\/p>\n Biochimie, Biologie, G\u00e9n\u00e9tique :<\/strong><\/p>\n – Suivi de la r\u00e9sistance aux compos\u00e9s chimiques ou biologiques antiviraux Responsable de Structure : Sylvie Van Der Werf Mathilde Ben Assaya : Technicienne Institut Pasteur<\/p>\n 25, rue du Dr Roux<\/p>\n 75724 PARIS CEDEX 15<\/p>\n<\/div>\n<\/div>\n<\/div>\n 75015<\/span>\u00a0PARIS<\/span><\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" GMVR \u00a0 Tutelles\u00a0> Institut Pasteur \u00a0 UFR de rattachement\u00a0> Sciences du Vivant \u00a0 \u00a0 Label unit\u00e9\u00a0> UMR 3569 \u00a0 Pr\u00e9sentation Les activit\u00e9s de l’unit\u00e9 sont centr\u00e9es sur la g\u00e9n\u00e9tique mol\u00e9culaire des virus \u00e0 ARN positif ou n\u00e9gatif (virus grippaux, coronavirus associ\u00e9 au SRAS, h\u00e9pacivirus).Elles portent sur l’\u00e9tude des m\u00e9canismes mol\u00e9culaires de l’expression et de… Lire la suite G\u00e9n\u00e9tique mol\u00e9culaire des virus \u00e0 ARN<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1622","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1622","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1622"}],"version-history":[{"count":3,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1622\/revisions"}],"predecessor-version":[{"id":1670,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1622\/revisions\/1670"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1622"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
– D\u00e9tection, quantification et identification antig\u00e9nique, biologique et g\u00e9n\u00e9tique des virus grippaux
– D\u00e9tection, quantification et identification des anticorps anti-grippaux
– Collection de souches et de s\u00e9rums de r\u00e9f\u00e9rence
– \u00c9valuation in vitro et in vivo de nouvelles approches prophylactiques et th\u00e9rapeutiques<\/p>\n
– Neuramidase, ac\u00e9tylest\u00e9rase, polym\u00e9rase<\/p>\n
– R\u00e9ponses d’immunit\u00e9 humorale et cellulaire
– Protection vis \u00e0 vis d’une infection d’\u00e9preuve
– Enqu\u00eates et validations sur le terrain<\/p>\n
– Validation de techniques et de protocoles de diagnostic<\/p>\n<\/div>\n<\/div>\n<\/div>\nEquipes de recherche<\/h3>\n
Vincent Enouf : Directeur(trice) Adjoint(e) de Centre National de R\u00e9f\u00e9rence<\/p>\n
Andreea Alexandru
St\u00e9phane Leandri
Camille Berthault
Marion Declercq : Etudiante en th\u00e8se
Melanie Dos Santos
Marie Lazzerini
Brigitte Blumen
Malika Hocine
Camille Roquin
Sylvie Behillil
Nadia Naffakh : Cheffe de Groupe
Florian Andrieux
Cyril Barbezange : Chercheur Permanent
Caroline Demeret
Guillaume Fournier : Post-doctorant
Sandie Munier
Bernadette Crescenzo : Ing\u00e9nieure de Recherche
Julie Magnus : Ing\u00e9nieure de Recherche
Lisette Cohen
Matthieu Fritz : Etudiant en th\u00e8se
Patricia Cassonnet : Ing\u00e9nieure de Recherche
St\u00e9phanie Aicher : Etudiante en th\u00e8se
Elise Biquand : Etudiante en th\u00e8se
C\u00e9dric Diot : Etudiant en th\u00e8se
Yves Jacob : Chef de Groupe
Annette Martin : Cheffe de Groupe
Isabelle Poste : Personnel Administratif<\/p>\n<\/div>\n<\/div>\n<\/div>\nAUTRES CONTACTS<\/h3>\n
Localisation<\/h3>\n