{"id":1573,"date":"2021-01-09T08:24:27","date_gmt":"2021-01-09T07:24:27","guid":{"rendered":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/?page_id=1573"},"modified":"2021-01-10T17:06:14","modified_gmt":"2021-01-10T16:06:14","slug":"integrated-red-blood-cell-biology","status":"publish","type":"page","link":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/integrated-red-blood-cell-biology\/","title":{"rendered":"Integrated Red Blood Cell Biology"},"content":{"rendered":"<p>[et_pb_section bb_built=\u00a0\u00bb1&Prime; next_background_color=\u00a0\u00bb#000000&Prime; inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb4_4&Prime;][et_pb_post_title _builder_version=\u00a0\u00bb3.22.1&Prime; meta=\u00a0\u00bboff\u00a0\u00bb featured_image=\u00a0\u00bboff\u00a0\u00bb text_shadow_horizontal_length=\u00a0\u00bbtext_shadow_style,%91object Object%93&Prime; text_shadow_vertical_length=\u00a0\u00bbtext_shadow_style,%91object Object%93&Prime; 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header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93&Prime; z_index_tablet=\u00a0\u00bb500&Prime;]<\/p>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-acronyme h4\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-labo-acronyme field-type-text field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">BIGR<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-tutelle-principale\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-labo-tutelle-principale field-type-text field-label-inline inline\">\n<div class=\"field-label\">Tutelles\u00a0&gt;<\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">Universit\u00e9 Paris Diderot &#8211; Paris 7<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-ufr-rattachement\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-labo-ufr-rattachement field-type-text field-label-inline inline\">\n<div class=\"field-label\">UFR de rattachement\u00a0&gt;<\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">UFR Sciences du Vivant<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-rattachement-ppl\">\n<div class=\"pane-content\">\u00a0<\/div>\n<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-label-unite node-categories\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-labo-label-unite field-type-text field-label-inline inline\">\n<div class=\"field-label\">Label unit\u00e9\u00a0&gt;<\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">UMRS<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-labo-autres-rattachement\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-labo-autres-rattachement field-type-text field-label-inline inline\">\n<div class=\"field-label\">Partenaires\u00a0&gt;<\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\">INSERM, U de la R\u00e9union, U Antilles &#8211; Guyane, Partenaire : INTS<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<h3>Pr\u00e9sentation<\/h3>\n<div class=\"field field-name-body field-type-text-with-summary field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>We are a mixed research unit Inserm UMR_S 1134 and University Paris Diderot \u2013 Paris 7 located at the French National Institute of Blood Transfusion (INTS).<\/p>\n<ul>\n<li>\u00a0<u>Objectives<\/u>\u00a0: Investigate physiological and molecular aspects of pathological mechanisms of erythrocytes by the use of cellular and mouse-models, human blood samples and patient cohorts, and complementary in-silico approaches.<\/li>\n<\/ul>\n<ul>\n<li><u>Methods<\/u>\u00a0: In-vitro, ex-vivo, in-vivo and in-silico approaches. Use of in-house platforms for flow cytometry, cellular imaging and bioinformatics.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<h3>Th\u00e8mes de recherche<\/h3>\n<div class=\"field field-name-field-labo-themes-recherche field-type-text-long field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>The works of the unit concern the clarification of the genic and protein structures of the antigens of blood groups, the molecular analysis of their polymorphisms and the understanding of the molecular mechanisms involved in certain hereditary disorders of the erythro\u00efd membrane.<\/p>\n<p>The unit focuses on the properties of human red blood cells (erythrocytes).<br \/>Experimental and in-silico methods are used for an integrative approach to the understanding of the interaction between extracellular ligands, transmembrane proteins and the cytoskeleton that define the antigenic properties (e.g. blood group) of erythrocytes.<br \/>These interactions are studied in normal and pathological situations (hereditary anemia, malaria, sickle-cell disease) with a particular interest in the structure and function of the plasma membrane of erythrocytes.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<h3>Equipes de recherche<\/h3>\n<div class=\"field field-name-field-labo-equipe-recherche field-type-text-long field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Equipe 1 : Caroline Le Van Kim &amp; Yves Colin (Physiologie du Globule Rouge Normal et Pathologique)<\/p>\n<p>Equipe 2 : Catherine Etchebest (Dynamique des Structures et Interactions des Macromol\u00e9cules Biologiques &#8211; DSIMB)<\/p>\n<p>Equipe 3 : Beno\u00eet Gamain (Pathog\u00e9n\u00e8se du paludisme s\u00e9v\u00e8re)<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<h3 class=\"niveau3\">AUTRES CONTACTS<\/h3>\n<div class=\"field field-name-field-labo-autres-contacts field-type-text-long field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<p>Directeur : Yves COLIN<\/p>\n<p>Universit\u00e9 Paris Diderot &#8211; Paris 7<\/p>\n<p>INTS<\/p>\n<p>6 Rue Alexandre Cabanel<\/p>\n<p>75015 PARIS<\/p>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<div class=\"panel-pane pane-entity-field pane-node-field-liens-web\">\n<div class=\"pane-content\">\n<div class=\"field field-name-field-liens-web field-type-link-field field-label-inline inline\">\n<div class=\"field-label\">Lien(s) web\u00a0&gt;<\/div>\n<div class=\"field-items\">\n<div class=\"field-item even\"><a class=\"ext extlink\" href=\"http:\/\/www.u1134.inserm.fr\/\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.u1134.inserm.fr<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"panel-separator\">\u00a0<\/div>\n<h3>Localisation<\/h3>\n<div class=\"field field-name-field-labo-localisation field-type-location field-label-hidden\">\n<div class=\"field-items\">\n<div class=\"field-item even\">\n<div class=\"location vcard\">\n<div class=\"adr\">\n<div class=\"street-address\">6 Rue Alexandre Cabanel<\/div>\n<div class=\"street-address\"><span class=\"postal-code\">75015<\/span>\u00a0<span class=\"locality\">PARIS<\/span><\/div>\n<div class=\"street-address\">France<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row][et_pb_column type=\u00a0\u00bb1_2&Prime;][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2&Prime;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<div class=\"et_pb_row et_pb_row_0 et_pb_row_empty\"><\/div>\n<div class=\"et_pb_row et_pb_row_1 et_pb_row_empty\"><\/div>\n<div class=\"et_pb_row et_pb_row_2 et_pb_row_empty\"><\/div>\n<div class=\"et_pb_row et_pb_row_3 et_pb_row_empty\"><\/div>\n<p> BIGR \u00a0 Tutelles\u00a0&gt; Universit\u00e9 Paris Diderot &#8211; Paris 7 \u00a0 UFR de rattachement\u00a0&gt; UFR Sciences du Vivant \u00a0 \u00a0 Label unit\u00e9\u00a0&gt; UMRS \u00a0 Partenaires\u00a0&gt; INSERM, U de la R\u00e9union, U Antilles &#8211; Guyane, Partenaire : INTS \u00a0 Pr\u00e9sentation We are a mixed research unit Inserm UMR_S 1134 and University Paris Diderot \u2013 Paris 7&hellip; <a class=\"continue\" href=\"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/integrated-red-blood-cell-biology\/\">Lire la suite<span> Integrated Red Blood Cell Biology<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1573","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1573","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1573"}],"version-history":[{"count":3,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1573\/revisions"}],"predecessor-version":[{"id":1660,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1573\/revisions\/1660"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}