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Certaines \u00e9quipes \u00e9tudient les m\u00e9canismes g\u00e9n\u00e9tiques, cellulaires et mol\u00e9culaires qui sous-tendent le d\u00e9veloppement des animaux, en particulier ceux qui contr\u00f4lent la formation du syst\u00e8me nerveux. Ils \u00e9tudient \u00e9galement l’\u00e9volution des processus de d\u00e9veloppement.<\/p>\n
D’autres \u00e9quipes sont int\u00e9ress\u00e9es par la r\u00e9glementation de l’ADN et le m\u00e9tabolisme des prot\u00e9ines. Cela inclut les processus fondamentaux de la maintenance du g\u00e9nome comme le contr\u00f4le de la r\u00e9plication de l’ADN et la r\u00e9paration des dommages ; la r\u00e9gulation de la transcription ; le trafic et la r\u00e9gulation du trafic cellulaire par ubiquitylation nucl\u00e9ocytoplasmique; la transformation des prot\u00e9ines, pliage et l’exportation.<\/p>\n
Dans la premi\u00e8re perspective transversale, plusieurs \u00e9quipes d\u00e9veloppent de nouvelles approches th\u00e9oriques et \/ ou pratiques pour acqu\u00e9rir une meilleure compr\u00e9hension des bases mol\u00e9culaires et cellulaires de maladies rares (maladies g\u00e9n\u00e9tiques) et les affections les plus courantes (cancer, maladies de la reproduction, les maladies auto-immunes, etc.). Enfin, dans la seconde perspective transversale certains groupes sont activement engag\u00e9s dans la recherche et le d\u00e9veloppement de nouvelles m\u00e9thodes et de ressources dans la mod\u00e9lisation math\u00e9matique et l’analyse biophysique des objets et ph\u00e9nom\u00e8nes biologiques.<\/p>\n
\u2666\u00a0Genome and chromosome dynamics<\/p>\n
\u2666\u00a0Cellular dynamics and signalling<\/p>\n
\u2666 Development and evolution<\/p>\n
Furthermore\u00a0two transverse themes<\/u>\u00a0consist in :<\/p>\n
a) Modelling, quantitative biology and biophysics
b) Molecular and cellular pathologies.<\/p>\n
Methods\u00a0<\/strong>: In-vivo and in-vitro approaches in model systems such as : yeast, drosophila, zebra fish, mouse, rat. Genetics, cellular and molecular biology (transcriptomics, proteomics, flow cytometry, cellular imaging).<\/p>\n<\/div>\n<\/div>\n<\/div>\n TEAMS\u00a0<\/strong><\/u>:<\/p>\n -Equipe 1 : Juliette Azimzadeh (Polarit\u00e9 cellulaire dans le d\u00e9veloppement et l’\u00e9volution)<\/p>\n -Equipe 2 : Guillaume Balavoine\/Michel Vervoort (\u00c9volution et d\u00e9veloppement des m\u00e9tazoaires)<\/p>\n -Equipe 3 : Giuseppe Baldacci (Pathologies de la r\u00e9plication de l’ADN)<\/p>\n -Equipe 4 : Nicolas Borghi ( M\u00e9canotransduction : de la surface de la cellule \u00e0 son noyau)<\/p>\n -Equipe 5 : Jean-Michel Camadro (Mitochondries, m\u00e9taux et stress oxydatif)<\/p>\n -Equipe 6 : J\u00e9r\u00f4me Collignon (Sp\u00e9cification des destins cellulaires chez la souris)<\/p>\n -Equipe 7 : Val\u00e9rie Doye (Fonctions non-conventionnelles des pores nucl\u00e9aires)<\/p>\n -Equipe 8 : Sandra Duharcourt (R\u00e9gulation \u00e9pig\u00e9n\u00e9tique de l’organisation du g\u00e9nome)<\/p>\n -Equipe 9 : Julien Dumont (Division cellulaire et reproduction)<\/p>\n -Equipe 10 : Thierry Galli (Trafic membranaire normal et pathologique)<\/p>\n -Equipe 11 : Thierry Grange\/Eva-Maria Geigl (\u00c9pig\u00e9nome et pal\u00e9og\u00e9nome)<\/p>\n -Equipe 12 : Antoine Guichet ( Polarit\u00e9 et morphogen\u00e8se)<\/p>\n -Equipe 13 : Cathy Jackson\/Jean-Marc Verbavatz (Dynamique des membranes et trafic intracellulaire)<\/p>\n -Equipe 14 : Isabelle Jupin (Virologie mol\u00e9culaire)<\/p>\n -Equipe 15 : Roger Karess (Dynamique et r\u00e9gulation de la division cellulaire)<\/p>\n -Equipe 16 : Beno\u00eet Ladoux\/ Ren\u00e9-Marc M\u00e8ge (Adh\u00e9sion cellulaire et m\u00e9canique)<\/p>\n -Equipe 17 : S\u00e9bastien Leon (Trafic membranaire, ubiquitine et signalisation)<\/p>\n -Equipe 18 : Domenico Libri (M\u00e9tabolisme et fonction de l’ARN dans le noyau)<\/p>\n -Equipe 19 : Nicolas Minc (Organisation spatiale de la cellule)<\/p>\n -Equipe 20 : Virginie Orgogozo (\u00c9volution des drosophiles)<\/p>\n -Equipe 21 : Khashayar Pakdaman (Biologie computationnelle et biomath\u00e9matiques)<\/p>\n -Equipe 22 : Alessandra Pierani (G\u00e9n\u00e9tique et d\u00e9veloppement du cortex c\u00e9r\u00e9bral)<\/p>\n -Equipe 23 : Lionel Pintard (Cycle cellulaire et d\u00e9veloppement)<\/p>\n -Equipe 24 : Anne Plessis (D\u00e9veloppement, signalisation et trafic)<\/p>\n -Equipe 25 : Fran\u00e7oise Poirier (Morphogen\u00e8se, hom\u00e9ostasie et pathologies)<\/p>\n -Equipe 26 : Marie-No\u00eblle Prioleau (Domaines chromatiniens et r\u00e9plication)<\/p>\n -Equipe 27 : Vanessa Ribes (R\u00e9seaux transcriptionnels et diff\u00e9renciation neurale)<\/p>\n -Equipe 28 : Guillaume Romet-Lemonne (R\u00e9gulation de la dynamique d’assemblage de l’actine)<\/p>\n -Equipe 29 : Terence Strick (Nanomanipulation de biomol\u00e9cules)<\/p>\n -Equipe 30 : Reiner Veitia (Oncologie mol\u00e9culaire et pathologies ovariennes)<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb3.22″ background_size=\u00a0\u00bbinitial\u00a0\u00bb background_position=\u00a0\u00bbtop_left\u00a0\u00bb background_repeat=\u00a0\u00bbrepeat\u00a0\u00bb][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_2″][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Tutelles\u00a0> Universit\u00e9 Paris Diderot \u00a0 UFR de rattachement\u00a0> SCIENCES DU VIVANT \u00a0 Label unit\u00e9\u00a0> UMR 7592 \u00a0 Partenaires\u00a0> CNRS \u00a0 Pr\u00e9sentation Objectifs\u00a0: L’objectif des \u00e9quipes de recherche est de comprendre les processus fondamentaux qui contribuent \u00e0 la structure, la dynamique et les fonctions des cellules eucaryotes. Diff\u00e9rents composants cellulaires sont \u00e9tudi\u00e9s (noyaux, v\u00e9sicules de… Lire la suite Institut Jacques Monod<\/span><\/a><\/p>\n","protected":false},"author":69,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-1544","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1544","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/users\/69"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/comments?post=1544"}],"version-history":[{"count":3,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1544\/revisions"}],"predecessor-version":[{"id":1646,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/pages\/1544\/revisions\/1646"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sdv\/wp-json\/wp\/v2\/media?parent=1544"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Equipes de recherche<\/h3>\n
Localisation<\/h3>\n