{"id":2597,"date":"2023-03-08T10:37:52","date_gmt":"2023-03-08T09:37:52","guid":{"rendered":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/?p=2597"},"modified":"2023-03-08T13:19:06","modified_gmt":"2023-03-08T12:19:06","slug":"reorganisations-3d-de-la-chromatine-induites-par-le-stress-thermique","status":"publish","type":"post","link":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/reorganisations-3d-de-la-chromatine-induites-par-le-stress-thermique\/","title":{"rendered":"R\u00e9organisations 3D de la chromatine induites par le stress thermique"},"content":{"rendered":"

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La complexit\u00e9 et la dynamique de l’organisation tridimensionnelle de la chromatine dans le noyau rend difficile la compr\u00e9hension du contr\u00f4le de l’expression des g\u00e8nes, mais ouvre aussi potentiellement des voies pour moduler \u00e9pig\u00e9n\u00e9tiquement l’expression des g\u00e8nes. Dans quelle mesure, et comment, un stress induit des changements dynamiques dans la r\u00e9organisation de la chromatine reste cependant mal compris. Dans une \u00e9tude publi\u00e9e dans Nature Communications<\/a> par l’\u00e9quipe CHROCYC<\/a> de l\u2019IPS2, les modifications de la chromatine \u00e0 l’\u00e9chelle du g\u00e9nome associ\u00e9es \u00e0 la reprogrammation transcriptionnelle en r\u00e9ponse \u00e0 un stress thermique ont \u00e9t\u00e9 \u00e9tudi\u00e9es de mani\u00e8re approfondie chez la tomate. Le stress thermique induit des changements rapides dans l’architecture de la chromatine, conduisant \u00e0 la formation transitoire de contacts promoteur-\u00ab\u00a0enhancer\u00a0\u00bb, et entra\u00eenant probablement l’activation de l\u2019expression de g\u00e8nes sensibles au stress thermique. De plus, les r\u00e9organisations spatiales de la chromatine induites par le stress thermique n\u00e9cessitent HSFA1a, un facteur de transcription (TF) essentiel pour la tol\u00e9rance au stress thermique chez la tomate. Ces r\u00e9sultats indiquent que la reconfiguration 3D des contacts promoteur-\u00ab\u00a0enhancer\u00a0\u00bb permet aux TFs de contr\u00f4ler dynamiquement les r\u00e9ponses transcriptionnelles au stress thermique.<\/p>\n

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L\u00e9gende de la figure :<\/strong> Mod\u00e8le r\u00e9capitulant le r\u00f4le de HSFA1a dans la formation de boucles \u00ab enhancer \u00bb-promoteur pour r\u00e9guler l’expression des g\u00e8nes en r\u00e9ponse au stress thermique chez la tomate <\/em>RNAPII, ARN Polym\u00e9rase II\u00a0; HSF1a, Heat Shock Factor A1a; H, Histone; ac, ac\u00e9tylation.<\/em><\/p>\n

A lire :\u00a0la derni\u00e8re publication de Moussa Benhamed @IPS2 sur la fa\u00e7on dont le stress thermique des plantes module l’organisation de la chromatine 3D des interactions activateur-promoteur via le facteur de transcription HSFA1a<\/span><\/strong><\/p>\n

https:\/\/www.nature.com\/articles\/s41467-023-36227-3<\/a><\/p>\n

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La complexit\u00e9 et la dynamique de l’organisation tridimensionnelle de la chromatine dans le noyau rend difficile la compr\u00e9hension du contr\u00f4le de l’expression des g\u00e8nes, mais ouvre aussi potentiellement des voies pour moduler \u00e9pig\u00e9n\u00e9tiquement l’expression des g\u00e8nes. Dans quelle mesure, et comment, un stress induit des changements dynamiques dans la r\u00e9organisation de la chromatine reste… Lire la suite R\u00e9organisations 3D de la chromatine induites par le stress thermique<\/span><\/a><\/p>\n","protected":false},"author":397,"featured_media":2607,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1],"tags":[],"class_list":["post-2597","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-faculte-de-sciences"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/posts\/2597","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/users\/397"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/comments?post=2597"}],"version-history":[{"count":7,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/posts\/2597\/revisions"}],"predecessor-version":[{"id":2609,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/posts\/2597\/revisions\/2609"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/media\/2607"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/media?parent=2597"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/categories?post=2597"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/sciences\/wp-json\/wp\/v2\/tags?post=2597"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}