[et_pb_section bb_built=\u00a0\u00bb1″ next_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row][et_pb_column type=\u00a0\u00bb3_4″][et_pb_text admin_label=\u00a0\u00bbIntro\u00a0\u00bb _builder_version=\u00a0\u00bb3.22.1″ module_id=\u00a0\u00bbintro\u00a0\u00bb text_text_shadow_horizontal_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_vertical_length=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ text_text_shadow_blur_strength=\u00a0\u00bbtext_text_shadow_style,%91object Object%93″ link_text_shadow_horizontal_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_vertical_length=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ link_text_shadow_blur_strength=\u00a0\u00bblink_text_shadow_style,%91object Object%93″ ul_text_shadow_horizontal_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_vertical_length=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ul_text_shadow_blur_strength=\u00a0\u00bbul_text_shadow_style,%91object Object%93″ ol_text_shadow_horizontal_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_vertical_length=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ ol_text_shadow_blur_strength=\u00a0\u00bbol_text_shadow_style,%91object Object%93″ quote_text_shadow_horizontal_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_vertical_length=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ quote_text_shadow_blur_strength=\u00a0\u00bbquote_text_shadow_style,%91object Object%93″ header_text_shadow_horizontal_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_vertical_length=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_text_shadow_blur_strength=\u00a0\u00bbheader_text_shadow_style,%91object Object%93″ header_2_text_shadow_horizontal_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_vertical_length=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_2_text_shadow_blur_strength=\u00a0\u00bbheader_2_text_shadow_style,%91object Object%93″ header_3_text_shadow_horizontal_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_vertical_length=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_3_text_shadow_blur_strength=\u00a0\u00bbheader_3_text_shadow_style,%91object Object%93″ header_4_text_shadow_horizontal_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_vertical_length=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_4_text_shadow_blur_strength=\u00a0\u00bbheader_4_text_shadow_style,%91object Object%93″ header_5_text_shadow_horizontal_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_vertical_length=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_5_text_shadow_blur_strength=\u00a0\u00bbheader_5_text_shadow_style,%91object Object%93″ header_6_text_shadow_horizontal_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength=\u00a0\u00bbheader_6_text_shadow_style,%91object Object%93″ z_index_tablet=\u00a0\u00bb500″]<\/p>\n
Paris, le 15 f\u00e9vrier 2022 \u2013 L’Institut Cochin, Universit\u00e9 Paris Cit\u00e9, la Fondation Universit\u00e9 Paris Cit\u00e9 et Elsevier ont d\u00e9cern\u00e9 aujourd’hui \u00e0 Olivier Kosmider et J\u00e9r\u00f4me Avouac les prix de l\u2019innovation Elsevier – Institut Cochin 2020 et 2021.<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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\u00a9 Universit\u00e9 Paris Cit\u00e9<\/p>\n<\/div>\n<\/div>\n<\/div>\n
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Le Prix de l\u2019Innovation Elsevier-Institut Cochin s\u2019inscrit dans le cadre du programme \u00ab\u00a0Proof-of-Concept\u00a0\u00bb de l\u2019Institut Cochin<\/a>, qui encourage chaque ann\u00e9e les chercheurs dont les travaux ont fait la preuve d\u2019une application concr\u00e8te, afin de leur permettre d\u2019apporter des solutions th\u00e9rapeutiques innovantes \u00e0 des probl\u00e9matiques m\u00e9dicales et de sant\u00e9 publique. Universit\u00e9 Paris Cit\u00e9<\/a>\u00a0et\u00a0Elsevier<\/a>\u00a0collaborent pour faire reconna\u00eetre les r\u00e9alisations scientifiques et l\u2019innovation dans la recherche et l\u2019enseignement en France.<\/p>\n Le Pr. J\u00e9r\u00f4me Avouac<\/strong> est rhumatologue \u00e0 l\u2019H\u00f4pital Cochin AP-HP et Enseignant Chercheur au sein d’Universit\u00e9 Paris Cit\u00e9 et de l\u2019Institut Cochin. Dans l\u2019\u00e9quipe \u00ab Pathog\u00e9nie et traitements innovants des maladies fibro-inflammatoires chroniques\u00a0\u00bb, il s\u2019int\u00e9resse particuli\u00e8rement au d\u00e9veloppement de nouvelles voies th\u00e9rapeutiques dans la scl\u00e9rodermie syst\u00e9mique (SSc), maladie auto-immune complexe qui se caract\u00e9rise par une inflammation excessive non r\u00e9solue entra\u00eenant le d\u00e9veloppement d\u2019une fibrose de la peau et des organes. L\u2019\u00e9quipe a d\u00e9velopp\u00e9 une plateforme de mod\u00e8les animaux compl\u00e9mentaires de fibrose dermique, pulmonaire et vasculaire permettant une \u00e9valuation compl\u00e8te de nouvelles voies th\u00e9rapeutiques.<\/p>\n Le projet prim\u00e9 a pour objectif d\u2019\u00e9valuer l\u2019effet de l\u2019aplasie B induite par l\u2019injection de cellules CAR-T CD19 sur le d\u00e9veloppement de la fibrose et de l\u2019hypertension pulmonaires dans le mod\u00e8le murin transg\u00e9nique Fra-2, qui reproduit les principales atteintes de la SSc avec la m\u00eame s\u00e9quence temporelle que la maladie humaine. Les CAR-T CD19 induisent une aplasie B totale et durable et ont permis des r\u00e9sultats spectaculaires dans le traitement des h\u00e9mopathies B.<\/p>\n Les enjeux scientifiques de ce projet pourraient \u00eatre tr\u00e8s importants. Il s\u2019agirait d\u2019une premi\u00e8re d\u00e9monstration de l\u2019efficacit\u00e9 des CAR-T CD19 dans un mod\u00e8le pr\u00e9clinique valid\u00e9 et robuste de SSc, la preuve de concept ainsi apport\u00e9e ouvrirait un large champ pour l\u2019\u00e9valuation clinique des CAR-T CD19 dans une maladie qui manque d\u2019options th\u00e9rapeutiques efficaces. Ces r\u00e9sultats renforceraient \u00e9galement le rationnel de leur utilisation clinique dans les maladies auto-immunes.<\/p>\n Le Pr. Olivier Kosmider<\/strong> est h\u00e9matologue \u00e0 l’H\u00f4pital Cochin, membre de l’\u00e9quipe \u00ab H\u00e9matopo\u00ef\u00e8se normale et pathologique \u00bb de l’Institut Cochin. Il est sp\u00e9cialiste des syndromes my\u00e9lodysplasiques (SMD), maladies de la cellule souche h\u00e9matopo\u00ef\u00e9tique qui pr\u00e9sentent une h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 ph\u00e9notypique et pour lesquelles il n\u2019existe pas de biomarqueur robuste de r\u00e9ponse au traitement applicable en routine.\u00a0 Les SMD avec sid\u00e9roblastes en couronnes (SMD-RS) sont une cat\u00e9gorie de SMD pr\u00e9sentant des mutations somatiques du g\u00e8ne SF3B1<\/em> chez environ 90% des patients SMD-RS, ce qui en fait une entit\u00e9 mol\u00e9culairement identifiable dans la classification des h\u00e9mopathies my\u00e9lo\u00efdes propos\u00e9e par l\u2019OMS depuis 2016.<\/p>\n Par des analyses haut d\u00e9bit, l\u2019\u00e9quipe d\u2019Olivier Kosmider a identifi\u00e9 dans les SMD-RS un transcrit variant de l\u2019\u00e9rythroferrone ou ERFE+12<\/sup> dont la quantification est un facteur pr\u00e9dictif de surcharge en fer dans le sang. Cette d\u00e9couverte, qui est la cons\u00e9quence de la pr\u00e9sence de la mutation de SF3B1 dans les cellules \u00e9rythro\u00efdes de la moelle, a permis d\u2019envisager un test utile au monitoring des patients sous traitement.<\/p>\n L\u2019objectif du projet prim\u00e9 est donc d\u2019obtenir un dosage sp\u00e9cifique de la prot\u00e9ine ERFE variante (ERFEVPFQ<\/sup>) avec application directe \u00e0 la prise en charge des patients en collaboration avec l\u2019\u00e9quipe du Dr L\u00e9on Kautz (Toulouse). Ce dosage est en cours de validation \u00e0 l\u2019aide d\u2019outils (anticorps sp\u00e9cifiques) et sera mis prochainement \u00e0 la disposition de la communaut\u00e9 m\u00e9dicale comme un biomarqueur robuste de l\u2019\u00e9rythropo\u00ef\u00e8se clonale des patients SMD-RS avec mutation SF3B1,<\/em> au sein d\u2019essais cliniques prospectifs du Groupe Francophone des My\u00e9lodysplasies.<\/p>\n \u00ab\u00a0Notre mission est d\u2019accompagner et de valoriser l’excellence de la recherche et nous sommes reconnaissants et honor\u00e9s de nous associer \u00e0 des organisations aussi remarquables que l’Institut Cochin et Universit\u00e9 Paris Cit\u00e9 \u00ab\u00a0, a d\u00e9clar\u00e9 William Rubens, directeur France chez Elsevier. \u00ab\u00a0Nous sommes heureux de r\u00e9compenser le Pr Olivier Kosmider et le Pr J\u00e9r\u00f4me Avouac, deux chercheurs qui apportent non seulement une contribution significative \u00e0 leur domaine de recherche, mais aussi \u00e0 la soci\u00e9t\u00e9 dans son ensemble en contribuant au diagnostic et au traitement des maladies sanguines et auto-immunes.\u00a0\u00bb<\/p>\n Depuis 2017, le Prix de l’innovation Elsevier-Institut Cochin r\u00e9compense les projets de recherche innovants \u00e0 fort potentiel de transfert vers l’industrie pharmaceutique, les entreprises de biotechnologie ou le patient. L’Institut Cochin et Elsevier travaillent ensemble avec un objectif commun : soutenir l’innovation dans la recherche biom\u00e9dicale fran\u00e7aise.<\/p>\n<\/div>\n<\/div>\n<\/div>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00a0\u00bb1_4″][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=\u00a0\u00bb1″ specialty=\u00a0\u00bboff\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″ custom_padding=\u00a0\u00bb0px||0px|\u00a0\u00bb prev_background_color=\u00a0\u00bb#000000″ inner_width=\u00a0\u00bbauto\u00a0\u00bb inner_max_width=\u00a0\u00bbnone\u00a0\u00bb][et_pb_row _builder_version=\u00a0\u00bb3.19.11″ width=\u00a0\u00bb80%\u00a0\u00bb max_width=\u00a0\u00bb1080px\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4″][et_pb_text admin_label=\u00a0\u00bb\u00c0 lire aussi\u00a0\u00bb _builder_version=\u00a0\u00bb3.21″]<\/p>\n [\/et_pb_text][et_pb_blog _builder_version=\u00a0\u00bb3.21″ posts_number=\u00a0\u00bb4″ include_categories=\u00a0\u00bb13″ show_author=\u00a0\u00bboff\u00a0\u00bb show_date=\u00a0\u00bboff\u00a0\u00bb show_pagination=\u00a0\u00bboff\u00a0\u00bb border_width_bottom_fullwidth=\u00a0\u00bb1px\u00a0\u00bb border_color_bottom_fullwidth=\u00a0\u00bbrgba(51,51,51,0.18)\u00a0\u00bb custom_padding=\u00a0\u00bb||50px|\u00a0\u00bb module_id=\u00a0\u00bbpage_type_blog\u00a0\u00bb header_level=\u00a0\u00bbh4″ \/][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Paris, le 15 f\u00e9vrier 2022 \u2013 L’Institut Cochin, Universit\u00e9 Paris Cit\u00e9, la Fondation Universit\u00e9 Paris Cit\u00e9 et Elsevier ont d\u00e9cern\u00e9 aujourd’hui \u00e0 Olivier Kosmider et J\u00e9r\u00f4me Avouac les prix de l\u2019innovation Elsevier – Institut Cochin 2020 et 2021. Prix de l’innovation Elsevier – Institut Cochin 2020-2021 <\/p>\n\u00c0<\/span> lire aussi<\/h2>\n