{"id":26400,"date":"2022-05-18T11:20:50","date_gmt":"2022-05-18T09:20:50","guid":{"rendered":"https:\/\/wordpress-test.app.u-pariscite.fr\/medecine\/?p=26400"},"modified":"2022-05-18T14:41:28","modified_gmt":"2022-05-18T12:41:28","slug":"pr-jean-louis-mas-grand-laureat-prix-scientifique-2022-de-la-fondation-lefoulon-delalande-institut-de-france","status":"publish","type":"post","link":"https:\/\/wordpress-test.app.u-pariscite.fr\/medecine\/pr-jean-louis-mas-grand-laureat-prix-scientifique-2022-de-la-fondation-lefoulon-delalande-institut-de-france\/","title":{"rendered":"Pr. Jean-Louis MAS, laur\u00e9at du Grand Prix scientifique 2022 de la Fondation Lefoulon-Delalande-Institut de France"},"content":{"rendered":"

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Jean-Louis MAS est Professeur de Neurologie \u00e0 l\u2019Universit\u00e9 Paris-Cit\u00e9 et chef du service de Neurologie de l\u2019h\u00f4pital Sainte-Anne \u00e0 Paris. Il dirige une \u00e9quipe de recherche sur les accidents vasculaires c\u00e9r\u00e9braux (AVC), au sein de l\u2019Institut de Psychiatrie et Neurosciences de Paris (Inserm 1266). Il a \u00e9t\u00e9 pr\u00e9sident de la Soci\u00e9t\u00e9 Fran\u00e7aise Neuro-Vasculaire et de la Soci\u00e9t\u00e9 Fran\u00e7aise de Neurologie. Il est membre correspondant de l\u2019Acad\u00e9mie nationale de m\u00e9decine et pr\u00e9sident fondateur de la Fondation pour la Recherche sur les AVC.<\/p>\n

Ses travaux de recherche concernent principalement les causes des infarctus c\u00e9r\u00e9braux, leur pronostic, notamment en termes de risque de r\u00e9cidive d\u2019infarctus c\u00e9r\u00e9bral, et l\u2019\u00e9valuation de strat\u00e9gies de pr\u00e9vention des r\u00e9cidives.<\/p>\n

Le Grand Prix scientifique 2022 de la Fondation Lefoulon-Delalande lui sera remis le 1er Juin 2022 \u00e0 l’Institut.<\/p>\n

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Pr. Jean-Louis MAS
Universit\u00e9 de Paris Cit\u00e9
Inserm U1266
Service de Neurologie et Unit\u00e9 Neurovasculaire
GHU Paris, H\u00f4pital Sainte-Anne<\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Le professeur Jean-Louis Mas est reconnu internationalement pour ses travaux, notamment ceux sur le foramen ovale perm\u00e9able et sur les st\u00e9noses carotides ath\u00e9roscl\u00e9reuses, qui ont permis des avanc\u00e9es importantes dans la prise en charge des patients. Il est l\u2019auteur de nombreuses publications, dont plusieurs dans des revues m\u00e9dicales prestigieuses, comme le New England Journal of Medicine, le Lancet ou le JAMA.<\/p>\n

Projet r\u00e9compens\u00e9<\/h3>\n

Les travaux r\u00e9compens\u00e9s par ce prix concernent le r\u00f4le du foramen ovale perm\u00e9able (FOP) dans la survenue d\u2019infarctus c\u00e9r\u00e9braux inexpliqu\u00e9s chez l\u2019adulte de moins de 60 ans. Le FOP est la persistance apr\u00e8s la naissance d\u2019un orifice physiologique de la cloison s\u00e9parant les oreillettes. Dans une \u00e9tude princeps, le professeur Lechat et le professeur Mas ont montr\u00e9 que cette anomalie cardiaque est significativement plus fr\u00e9quente chez les adultes jeunes victimes d\u2019un infarctus c\u00e9r\u00e9bral inexpliqu\u00e9 que chez des t\u00e9moins, et pourrait expliquer de nombreux infarctus c\u00e9r\u00e9braux survenant avant 60 ans. Les travaux du professeur Mas ont ensuite montr\u00e9 que\u00a0 : (a) la pr\u00e9sence d\u2019une hypermobilit\u00e9 de la cloison entre les oreillettes, appel\u00e9e an\u00e9vrisme du septum interauriculaire (ASIA), renforce la probabilit\u00e9 d\u2019un lien causal entre le FOP et l\u2019infarctus c\u00e9r\u00e9bral ; (b) les patients ayant un FOP et un ASIA ont un risque particuli\u00e8rement \u00e9lev\u00e9 de r\u00e9cidive d\u2019infarctus c\u00e9r\u00e9bral. Enfin, le professeur Mas a coordonn\u00e9 un essai randomis\u00e9 multicentrique chez des adultes de moins de 60 ans ayant un FOP associ\u00e9 \u00e0 un ASIA ou un FOP de taille importante, montrant que la fermeture du FOP par cath\u00e9t\u00e9risme cardiaque r\u00e9duit consid\u00e9rablement les r\u00e9cidives d\u2019infarctus c\u00e9r\u00e9bral, une avanc\u00e9e th\u00e9rapeutique majeure pour environ 250 000 adultes jeunes victimes chaque ann\u00e9e dans le monde d\u2019un infarctus c\u00e9r\u00e9bral li\u00e9 \u00e0 cette anomalie cardiaque. Les travaux du professeur Mas se poursuivent pour savoir dans quelle mesure les patients \u00e2g\u00e9s de plus de 60 ans pourraient b\u00e9n\u00e9ficier de ce traitement.<\/p>\n

Le professeur Mas remercie la fondation Lefoulon-Delalande-Institut de France et son jury scientifique pour ce prix prestigieux. Il souhaite aussi remercier tous ceux, neurologues, cardiologues et personnels des structures de recherche clinique hospitali\u00e8re, qui, depuis plus de 3 d\u00e9cennies, ont contribu\u00e9 \u00e0 ces travaux, avec une mention particuli\u00e8re pour ses coll\u00e8gues Laure Cabanes, Gilles Chatellier, Genevi\u00e8ve Derumeaux et Philippe Lechat, ainsi que pour les membres de son service et de son \u00e9quipe de recherche.<\/p>\n

2020:<\/strong>\u00a0 Prix Jean-Paul Binet de la Fondation pour la Recherche M\u00e9dicale.
2019:<\/strong> European Stroke Organization Presidential Award for significant impact in the field of stroke care internationally over many years.
2018:<\/strong> Membre correspondant de l\u2019Acad\u00e9mie nationale de m\u00e9decine.
2017:<\/strong> Prix Alain Castaigne de la Soci\u00e9t\u00e9 Fran\u00e7aise de Cardiologie.
2017:<\/strong> Prix de l\u2019Acad\u00e9mie nationale de m\u00e9decine.
2013:<\/strong> Prix des \u00e9tudes embl\u00e9matiques des 20 ans du Programme Hospitalier de Recherche Clinique, Minist\u00e8re de la Sant\u00e9.<\/p>\n

Communiqu\u00e9 de presse du Mercredi 4 mai 2022 Grand Prix scientifique 2022 de la Fondation Lefoulon-Delalande- Institut de France<\/strong><\/a><\/p>\n

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\u00c0<\/span> lire aussi<\/h2>\n

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Jean-Louis Mas est Professeur de Neurologie \u00e0 l\u2019Universit\u00e9 Paris-Cit\u00e9 et chef du service de Neurologie de l\u2019h\u00f4pital Sainte-Anne \u00e0 Paris. Il dirige une \u00e9quipe de recherche sur les accidents vasculaires c\u00e9r\u00e9braux (AVC), au sein de l\u2019Institut de Psychiatrie et Neurosciences de Paris (Inserm 1266). Lire la suite Pr. Jean-Louis MAS, laur\u00e9at du Grand Prix scientifique 2022 de la Fondation Lefoulon-Delalande-Institut de France<\/span><\/a><\/p>\n","protected":false},"author":234,"featured_media":26402,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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