[et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.22″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”1_4″ _builder_version=”3.0.47″][et_pb_text _builder_version=”3.22.1″ background_color=”#072c72″ border_color_all=”#3255c9″ text_orientation=”right” background_layout=”dark” custom_padding=”20px|15px|15px|” z_index_tablet=”500″]<\/p>\n
2021<\/em><\/p>\n Strategic Projects<\/em><\/p>\n @Medicine<\/span><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.22.1″ text_orientation=”right” z_index_tablet=”500″]<\/p>\n +Computer Science<\/p>\n +Biology<\/p>\n \u00a0<\/p>\n #Single Cell<\/p>\n #Omics<\/p>\n #Data Integration<\/p>\n #Primary Immune Deficiencies<\/p>\n #Personalized Medicine<\/p>\n \u00a0<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”3_4″ _builder_version=”3.0.47″][et_pb_text _builder_version=”3.22.1″ z_index_tablet=”500″]<\/p>\n Primary Immune Deficiencies (PIDs) comprise different monogenic diseases related to developmental or functional dysfunction of one or several immune cell types. Autoimmunity\/inflammation in PIDs can arise from different causes and its onset and presentation is highly unpredictable. As classical approaches to cellular and molecular analysis have many limitations, we propose a transversal project that uses single-cell technologies combined with multi-OMICS analysis in a spectrum of genetically well-defined PIDs resulting in autoimmunity\/inflammation. The interpretation of the massive and complex data collected will be assisted by machine learning-driven network inferences and, therefore, enable the identification of personalised disease signatures. Our goal is to develop ground-breaking and transformative diagnostic and prognostic tools and to define personalised therapeutic approaches for pediatric patients suffering from autoimmunity\/inflammation linked to PIDs.<\/p>\n \u00a0<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row custom_margin=”120px||” _builder_version=”3.22.1″ locked=”off”][et_pb_column type=”4_4″ _builder_version=”3.22.1″][et_pb_divider _builder_version=”3.22.1″][\/et_pb_divider][et_pb_text admin_label=”\u00c0 lire aussi” _builder_version=”3.22.1″ z_index_tablet=”500″ locked=”off”]<\/p>\n [\/et_pb_text][et_pb_blog posts_number=”4″ include_categories=”41″ show_author=”off” show_date=”off” show_pagination=”off” module_id=”page_type_blog” _builder_version=”3.22.1″ header_level=”h4″ border_width_bottom_fullwidth=”1px” border_color_bottom_fullwidth=”rgba(51,51,51,0.18)” custom_padding=”||50px|” z_index_tablet=”500″ locked=”off”][\/et_pb_blog][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" 2021Strategic Projects@Medicine +Computer Science+Biology\u00a0#Single Cell#Omics#Data Integration#Primary Immune Deficiencies#Personalized Medicine\u00a0 Project SummaryPrimary Immune Deficiencies (PIDs) comprise different monogenic diseases related to developmental or functional dysfunction of one or several immune cell types. Autoimmunity\/inflammation in PIDs can arise from different causes and its onset and presentation is highly unpredictable. As classical approaches to cellular and molecular analysis… Lire la suite Autoimmunity\/inflammation Through RNAseq Analysis at the single Cell level for Therapeutic Innovation \u2013 ATRACTion<\/span><\/a><\/p>\n","protected":false},"author":560,"featured_media":2263,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[57,1,41,26],"tags":[],"class_list":["post-1555","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-57","category-diip","category-medicine","category-strategic-projects"],"_links":{"self":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/posts\/1555","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/users\/560"}],"replies":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/comments?post=1555"}],"version-history":[{"count":4,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/posts\/1555\/revisions"}],"predecessor-version":[{"id":2440,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/posts\/1555\/revisions\/2440"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/media\/2263"}],"wp:attachment":[{"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/media?parent=1555"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/categories?post=1555"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wordpress-test.app.u-pariscite.fr\/diip\/wp-json\/wp\/v2\/tags?post=1555"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Project Summary<\/strong><\/h3>\n
Micka\u00ebl M\u00e9nager<\/strong><\/h5>\n
Projects in the same discipline
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