{"id":16108,"date":"2023-09-13T14:53:15","date_gmt":"2023-09-13T12:53:15","guid":{"rendered":"https:\/\/wordpress-test.app.u-pariscite.fr\/centre-politiques-terre\/?p=16108"},"modified":"2023-10-02T13:47:31","modified_gmt":"2023-10-02T11:47:31","slug":"insulibre","status":"publish","type":"post","link":"https:\/\/wordpress-test.app.u-pariscite.fr\/centre-politiques-terre\/insulibre\/","title":{"rendered":"Insulibre"},"content":{"rendered":"

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Un si\u00e8cle apr\u00e8s sa d\u00e9couverte, l\u2019acc\u00e8s \u00e0 l\u2019insuline, l\u2019un des m\u00e9dicaments phare du diab\u00e8te, reste inaccessible pour la moiti\u00e9 des diab\u00e9tiques qui en ont besoin. Pour d\u00e9mocratiser la production d\u2019insuline, ce projet s\u2019attaque aux \u00e9tapes cl\u00e9s de la mise sur le march\u00e9 d\u2019un biosimilaire : le d\u00e9veloppement de micro-organismes modifi\u00e9s pour produire l\u2019insuline.<\/p>\n

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La production industrielle d\u2019insuline pour le traitement du diab\u00e8te a marqu\u00e9 l\u2019essor de la biotechnologie dans les ann\u00e9es 80. Pourtant, la production mondiale peine \u00e0 r\u00e9pondre aux demandes. Pr\u00e8s de la moiti\u00e9 des diab\u00e9tiques insulino-requ\u00e9rants -la majorit\u00e9 en Asie et en Afrique – ne pourront pas l’obtenir. D\u00e9j\u00e0, un patient sur deux n’a pas acc\u00e8s \u00e0 l’insuline dont il a besoin.<\/strong> Ce constat ne va faire qu\u2019empirer : la pr\u00e9valence du diab\u00e8te \u00e0 l\u2019\u00e9chelle mondiale ne cesse d\u2019augmenter (537 millions en 2021 et 783 millions en 2045). En France, des ruptures d’approvisionnement ont eu lieu en 2022 et 2023.<\/p>\n

L\u2019am\u00e9lioration de l\u2019acc\u00e8s \u00e0 l\u2019insuline se fera via une diversification des acteurs autant sur le plan \u00e9conomique, le march\u00e9 de l\u2019insuline est d\u00e9tenu \u00e0 90% par un oligopole, que sur le plan g\u00e9ographique, la majorit\u00e9 de l\u2019insuline est produite dans 3 villes (Indianapolis, Etats-Unis, Francfort, Allemagne et Kalundborg, Danemark). Le co\u00fbt d’entr\u00e9e sur ce march\u00e9 est important car le d\u00e9veloppement des infrastructures n\u00e9cessaire est important en temps et financi\u00e8rement. L\u2019une des infrastructures centrales est la ressource biologique que repr\u00e9sentent les organismes modifi\u00e9s et optimis\u00e9s pour produire l\u2019insuline.<\/p>\n

Le projet Insulibre a pour but d’\u00e9tablir une preuve de concept<\/strong> montrant qu\u2019il est possible avec peu de ressources de d\u00e9velopper les ressources biologiques pour la production de m\u00e9dicament en prenant l\u2019exemple de la production d\u2019insuline par des micro-organismes<\/strong>. La production scientifique sera disponible sous licence libre pour permettre une libre circulation des savoirs, des proc\u00e9d\u00e9s et des ressources.<\/strong><\/p>\n

Ce projet est le fruit d\u2019une collaboration entre l\u2019\u00e9quipe de Christophe Magnan \u00e0 Universit\u00e9 Paris Cit\u00e9 et la fondation Open Insulin France<\/a>. Il regroupe des chercheurs de diff\u00e9rentes disciplines et des associations de patients.<\/p>\n

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\u00c0<\/span> (re)lire<\/h2>\n

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